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Howard T Jacobs Selected Research

5-taurinomethyl-2-thiouridine

5/2005Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases.

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Howard T Jacobs Research Topics

Disease

21Mitochondrial Diseases (Mitochondrial Disease)
03/2019 - 12/2004
6Cytochrome-c Oxidase Deficiency
06/2018 - 04/2009
5Cardiomyopathies (Cardiomyopathy)
01/2019 - 02/2002
3Hypoxia (Hypoxemia)
01/2020 - 10/2010
3Neoplasms (Cancer)
03/2013 - 10/2012
3Deafness (Deaf Mutism)
12/2004 - 06/2002
2Starvation
11/2014 - 01/2010
2Seizures (Absence Seizure)
06/2014 - 12/2004
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2013 - 06/2012
2Heart Diseases (Heart Disease)
05/2010 - 02/2002
2MELAS Syndrome (Syndrome, MELAS)
03/2006 - 05/2005
1Inflammation (Inflammations)
01/2022
1Chronic Disease (Chronic Diseases)
01/2022
1Carcinoma (Carcinomatosis)
03/2021
1Heart Failure
01/2019
1Chronic Obstructive Pulmonary Disease (COPD)
01/2019
1AIDS-Related Complex (ARC)
01/2019
1Weight Gain
01/2019
1Genomic Instability
01/2016
1Female Infertility
06/2014
1Parkinson Disease (Parkinson's Disease)
10/2012
1Infertility (Sterility)
10/2012
1Decompression Sickness (Bends)
10/2011
1Myocardial Ischemia (Ischemic Heart Diseases)
05/2010
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
05/2010
1Osteosarcoma (Osteogenic Sarcoma)
12/2008
1Myotonia
10/2008
1Paralysis (Palsy)
10/2008
1Myotonic Disorders (Paramyotonia Congenita)
10/2008
1Premature Aging
12/2005
1Teratocarcinoma
08/2005
1Arthrogryposis renal dysfunction cholestasis syndrome
06/2005
1Inborn Genetic Diseases (Disease, Hereditary)
06/2005
1MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers)
05/2005
1Hearing Disorders (Hearing Disorder)
01/2005
1Nonsyndromic Deafness
01/2005
1Hearing Loss (Hearing Impairment)
01/2005
1Kyphosis
05/2004
1Cardiomegaly (Heart Hypertrophy)
05/2004
1Osteoporosis
05/2004
1Alopecia (Baldness)
05/2004
1Weight Loss (Weight Reduction)
05/2004
1Sudden Death
02/2002
1Coronary Disease (Coronary Heart Disease)
02/2002

Drug/Important Bio-Agent (IBA)

12Mitochondrial DNA (mtDNA)IBA
06/2014 - 02/2002
9alternative oxidaseIBA
01/2019 - 04/2009
6EnzymesIBA
01/2019 - 01/2010
4Proteins (Proteins, Gene)FDA Link
10/2012 - 06/2005
3Transfer RNA (tRNA)IBA
01/2018 - 05/2005
2Superoxides (Superoxide)IBA
01/2020 - 01/2013
2NAD (NADH)IBA
01/2020 - 01/2019
2Oxygen (Dioxygen)IBA
01/2020 - 10/2010
2BuffersIBA
01/2019 - 01/2019
2SugarsIBA
01/2016 - 01/2016
2Mitochondrial Proteins (Mitochondrial Protein)IBA
08/2014 - 12/2004
2DNA (Deoxyribonucleic Acid)IBA
10/2011 - 02/2002
2mitochondrial ribosomal protein S12IBA
01/2010 - 09/2009
2Leu Transfer RNAIBA
03/2006 - 05/2005
2Lys Transfer RNAIBA
05/2005 - 10/2003
2Ser Transfer RNAIBA
09/2004 - 06/2002
1InflammasomesIBA
01/2022
1RNA (Ribonucleic Acid)IBA
03/2021
1Cytochromes c (Cytochrome c)IBA
01/2020
1Pyruvic Acid (Pyruvate)IBA
03/2019
1Sulfides (Thioethers)IBA
01/2019
1quinone (benzoquinone)IBA
01/2019
1ChemokinesIBA
01/2019
1Oxidoreductases (Dehydrogenase)IBA
01/2019
1SmokeIBA
01/2019
1Ribosomal DNA (rDNA)IBA
01/2016
1Vitamin K 3 (Menadione)FDA Link
11/2014
1Biological ProductsIBA
04/2014
1Anti-Bacterial Agents (Antibiotics)IBA
03/2013
1Glucose (Dextrose)FDA LinkGeneric
11/2012
1Electron Transport Complex I (NADH-CoQ Reductase)IBA
11/2012
1Cholinergic Agents (Cholinergics)IBA
06/2012
1Transcription Factors (Transcription Factor)IBA
10/2010
1Proteasome Endopeptidase Complex (Proteasome)IBA
10/2010
1Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA
10/2010
1Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
10/2010
1Proline (L-Proline)FDA Link
10/2010
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2010
1Dietary Fats (Dietary Fat)IBA
01/2010
1CytochromesIBA
12/2009
1Heme (Haem)IBA
12/2009
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
04/2009
1Pharmaceutical PreparationsIBA
12/2008
1Sodium Channels (Sodium Channel)IBA
10/2008
1Codon (Codons)IBA
03/2006
1NucleotidesIBA
08/2005
1TaurineFDA Link
05/2005
15-taurinomethyl-2-thiouridineIBA
05/2005
1UridineIBA
05/2005
1AnticodonIBA
05/2005
1Ile Transfer RNAIBA
10/2003

Therapy/Procedure

4Therapeutics
01/2019 - 09/2012
1Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
01/2019
1Ketogenic Diet
01/2019